A possible explanation for this phenomena is that over millions of years, balanced relationships have evolved in nature.
Scientists studying natural systems may find it difficult to perturb this balance in favor of increased parasitism.
A host specific organism runs the risk of becoming extinct if it kills off all of its hosts.
This has at times been cited as a reason why "natural" biological control will never be practical for nematodes.
Although it may not be feasible to effect control with a single organism, combinations of organisms could be developed or organisms utilized in combination with cultural controls which might provide control comparable to chemical nematicides.